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References
Barnes, M. A., Carson, M. J., & Nair, M. G. (2015). Non-traditional cytokines: How catecholamines and adipokines influence macrophages in immunity, metabolism and the central nervous system. Cytokine, 72(2), 210–219. https://doi.org/10.1016/j.
Bluthe, R. M., Pawlowski, M., Suarez, S., Parnet, P., Pittman, Q., Kelley, K. W., & Dantzer, R. (1994). Synergy Between Tumor Necrosis Factor alpha and Interleukin-1 in the Induction of Sickness Behavior in Mice. Psychoneuroendocrinology, 19(2), 197–207.
Bluthé, R. M., Beaudu, C., Kelley, K. W., & Dantzer, R. (1995). Differential effects of IL-1ra on sickness behavior and weight loss induced by IL-1 in rats. Brain Research, 677(1), 171–176. https://doi.org/10.1016/0006-
Bluthe´, R.-M., Dantzer, R., & Kelley, K. W. (1992). Effects of interleukin-1 receptor antagonist on the behavioral effects of lipopolysaccharide in rat. Brain Research, 573(2), 318–320. https://doi.org/10.1016/0006-
Capuron, L., Hauser, P., Hinze-Selch, D., Miller, A. H., & Neveu, P. J. (2002). Treatment of cytokine-induced depression. Brain Behavior and Immunity, 16(5), 575–580. https://doi.org/10.1016/s0889-
Carpenter, L. L., Shattuck, T. T., Tyrka, A. R., Geracioti, T. D., & Price, L. H. (2011). Effect of childhood physical abuse on cortisol stress response. Psychopharmacology, 214(1), 367–375. https://doi.org/10.1007/
Cohen, S., Janicki-Deverts, D., Doyle, W. J., Miller, G. E., Frank, E., Rabin, B. S., & Turner, R. B. (2012). Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk. Proceedings of the National Academy of Sciences, 109(16), 5995–5999. https://doi.org/10.1073/pnas.
Dantzer, R., Bluthé, R. M., Gheusi, G., Cremona, S., Layé, S., Parnet, P., & Kelley, K. W. (1998). Molecular basis of sickness behavior. Annals of the New York Academy of Sciences, 856, 132–138. Retrieved from http://www.ncbi.nlm.nih.gov/
Dantzer, R., Bluthe, R. M., & Kelley, K. W. (1991). Androgen-dependent vasopressinergic neurotransmission attenuates interleukin-1-induced sickness behavior. Brain Research, 557(1–2), 115–120. https://doi.org/10.1016/0006-
Dantzer, R., Wollman, E. E., & Yirmiya, R. (Eds.). (1999). Cytokines, Stess, and Depression. New York, NY: Kluwer Academic / Plenum Publishers.
Davis, K. C., & Raizen, D. M. (2017). A mechanism for sickness sleep: lessons from invertebrates. Journal of Physiology, 595(16), 5415–5424. https://doi.org/10.1113/
Dong, J., Li, J., Cui, L., Wang, Y., Lin, J., Qu, Y., & Wang, H. (2018). Cortisol modulates inflammatory responses in LPS-stimulated RAW264.7 cells via the NF-ΚB and MAPK pathways. BMC Veterinary Research, 14(1), 1–10. https://doi.org/10.1186/
Dunn, A. J. (2000). Cytokine Activation of the HPA Axis. Annals of the New York Academy of Sciences, 917(1), 608–617. https://doi.org/10.1111/j.
Fischer, S., Strawbridge, R., Vives, A. H., & Cleare, A. J. (2017). Cortisol as a predictor of psychological therapy response in depressive disorders: Systematic review and meta-analysis. British Journal of Psychiatry, 210(2), 105–109. https://doi.org/10.1192/bjp.
Flierl, M. A., Rittirsch, D., Huber-Lang, M., Sarma, J. V., & Ward, P. A. (2008). Catecholamines-crafty weapons in the inflammatory arsenal of immune/inflammatory cells or opening pandora’s box? Molecular Medicine (Cambridge, Mass.), 14(3–4), 195–204. https://doi.org/10.2119/2007-
Foley, P., & Kirschbaum, C. (2010). Human hypothalamus-pituitary-adrenal axis responses to acute psychosocial stress in laboratory settings. Neuroscience and Biobehavioral Reviews, 35(1), 91–96. https://doi.org/10.1016/j.
Irwin, M. R., & Miller, A. H. (2007). Depressive disorders and immunity: 20 years of progress and discovery. Brain, Behavior, and Immunity, 21(4), 374–383.
Juster, R. P., McEwen, B. S., & Lupien, S. J. (2010). Allostatic load biomarkers of chronic stress and impact on health and cognition. Neuroscience and Biobehavioral Reviews, 35(1), 2–16. https://doi.org/10.1016/j.
Maier, S. F., & Watkins, L. R. (1998). Cytokines for psychologists – Implications of bidirectional immune-to-brain communication for understanding behaviour, mood and cognition. Physiol. Rev., 105(1), 83–107.
Miller, A. H., Pariante, C. M., & Pearce, B. D. (1999). Effects of Cytokines on Glucocorticoid Receptor Expression And Function. Cytokines, Stress, and Depression, 461, 107–116. https://doi.org/10.1007/978-0-
Miller, A. H., & Raison, C. L. (2016). The role of inflammation in depression: from evolutionary imperative to modern treatment target. Nature Reviews Immunology, 16(1), 22–34. https://doi.org/10.1038/nri.
Miller, G. E., Chen, E., & Zhou, E. S. (2007). If it goes up, must it come down? Chronic stress and the hypothalamic-pituitary-
Miller, G. E., Cohen, S., & Ritchey, A. K. (2002). Chronic psychological stress and the regulation of pro-inflammatory cytokines: A glucocorticoid-resistance model. Health Psychology, 21(6), 531–541.
Osburg, B., Peiser, C., Dömling, D., Schomburg, L., Ko, Y. T., Voigt, K., & Bickel, U. (2002). Effect of endotoxin on expression of TNF receptors and transport of TNF-alpha at the blood-brain barrier of the rat. American Journal of Physiology – Endocrinology and Metabolism, 283(5), E899–E908. https://doi.org/10.1152/
Pace, T. W. W., & Miller, A. H. (2009). Cytokines and glucocorticoid receptor signaling: Relevance to major depression. Annals of the New York Academy of Sciences, 1179, 86–105. https://doi.org/10.1111/j.
Pan, W., Stone, K. P., Hsuchou, H., Manda, V. K., Zhang, Y., & Kastin, A. J. (2011). Cytokine signaling modulates blood-brain barrier function. Current Pharmaceutical Design, 17(33), 3729–3740. https://doi.org/10.1016/j.
Phelps, C., & Korneva, E. (Eds.). (2008). Cytokine Receptors in the Brain. Amsterdam, The Netherlands: Elsevier B.V. https://doi.org/10.1016/S1567-
Powers, S. I., Laurent, H. K., Gunlicks-Stoessel, M., Balaban, S., & Bent, E. (2016). Depression and anxiety predict sex-specific cortisol responses to interpersonal stress. Psychoneuroendocrinology, 69, 172–179. https://doi.org/10.1016/j.
Ramer-Quinn, D. S., Baker, R. A., & Sanders, V. M. (1997). Activated T helper 1 and T helper 2 cells differentially express the beta-2-adrenergic receptor: a mechanism for selective modulation of T helper 1 cell cytokine production. Journal of Immunology (Baltimore, Md. : 1950), 159(10), 4857–4867. Retrieved from http://www.jimmunol.org/
Schoenborn, J. R., & Wilson, C. B. (2007). Regulation of Interferon-γ During Innate and Adaptive Immune Responses. Advances in Immunology, 96(07), 41–101. https://doi.org/10.1016/S0065-
Segerstrom, S. C., & Miller, G. E. (2004). Psychological Stress and the Human Immune System: A Meta- Analytic Study of 30 Years of Inquiry. Psychological Bulletin, 130(4), 601–630. https://doi.org/10.1016/j.
Sehic, E., & Blatteis, C. M. (1996). Blockade of lipopolysaccharide-induced fever by subdiaphragmatic vagotomy in guinea pigs, 726, 160–166.
Shariq, A. S., Brietzke, E., Rosenblat, J. D., Barendra, V., Pan, Z., & McIntyre, R. S. (2018). Targeting cytokines in reduction of depressive symptoms: A comprehensive review. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 83(October 2017), 86–91. https://doi.org/10.1016/j.
Shonkoff, J. P., Garner, A. S., Siegel, B. S., Dobbins, M. I., Earls, M. F., Garner, A. S., … Wood, D. L. (2012). The Lifelong Effects of Early Childhood Adversity and Toxic Stress. Pediatrics, 129(1), e232–e246. https://doi.org/10.1542/peds.
Skelly, D. T., Hennessy, E., Dansereau, M. A., & Cunningham, C. (2013). A Systematic Analysis of the Peripheral and CNS Effects of Systemic LPS, IL-1Β, TNF-α and IL-6 Challenges in C57BL/6 Mice. PLoS ONE, 8(7), 1–20. https://doi.org/10.1371/
Sofroniew, M. V. (2015). Astrocyte barriers to neurotoxic inflammation. Nature Reviews Neuroscience, 16(5), 249–263. https://doi.org/10.1038/
Varatharaj, A., & Galea, I. (2016). The blood-brain barrier in systemic inflammation. Brain, Behavior, and Immunity, 60, 1–12. https://doi.org/10.1016/j.bbi.
Wichmann, S., Kirschbaum, C., Böhme, C., & Petrowski, K. (2017). Cortisol stress response in post-traumatic stress disorder, panic disorder, and major depressive disorder patients. Psychoneuroendocrinology, 83(January), 135–141. https://doi.org/10.1016/j.
Xaio, H., Banks, W. A., Niehoff, M. L., & Morley, J. E. (2001). Effect of LPS on the permeability of the blood-brain barrier to insulin. Brain Research, 896(1–2), 36–42. https://doi.org/10.1016/S0006-
Zadka, Ł., Dzięgiel, P., Kulus, M., & Olajossy, M. (2017). Clinical Phenotype of Depression Affects Interleukin-6 Synthesis. Journal of Interferon & Cytokine Research, 37(6), 231–245. https://doi.org/10.1089/jir.
Zhou, J., Yan, J., Liang, H., & Jiang, J. (2014). Epinephrine Enhances the Response of Macrophages under LPS Stimulation. BioMed Research International, 2014, 1–9. https://doi.org/10.1155/2014/

The Float Tour Blog – Issue #17
We hosted our second Float Tour Workshop here in Toronto and stayed in town a bit longer than we normally do, allowing us to get acquainted with the city. The sprawling metropolis is an amalgamation of old world pioneering days and modern multiculturalism. It was founded in 1787, and some of the currently standing buildings pre-date even that. Ancient architecture stands next to contemporary monoliths, weaving a tapestry of antiquity and avant-garde in this fair city.

2016 Float Conference Program Introduction
It’s been my pleasure to write the introduction to the conference program for five years in a row, and each year I enjoy posting it up on this blog for everyone who didn’t make it out. I hope to see you all in 2017! – Graham

The Float Tour Blog – Issue #16
We finally took this trip international! Explaining Float Tour to the border guards was a little bit of a challenge (especially through the language barrier), but – after some creative hand gestures and finding synonyms for “sensory” and “deprivation” – we made it through.

The Float Tour Blog – Issue #15
New York is where it’s at, and it’s arguably the busiest place on the planet. People here live fast-paced lives and rarely – if ever – have time to slow the fuck down and enjoy themselves.
Just like Jersey, people here also see skepticism as a point of pride, and take it to an even greater extreme. All of this makes New York a sort of “proving grounds” for floating: if it can make it in New York, it can make it anywhere.

The Float Tour Blog – Issue #14
The Garden State houses probably the highest concentration of float tanks on the East Coast. Jersey is a gateway to the major metropolitan areas nearby: New York City, Philadelphia, and Washington D.C.
This convenience has made Jersey the suburban hub for every major industry on the East Coast for generations, giving it the highest population density of any state in the U.S. This is fantastic for the float industry; if there’s one statistic that correlates with successful float centers, it’s population density.

The Float Tour Blog – Issue #13
Passing through Virginia and Maryland, we thought that if all serving politicians, lobbyists, Supreme Court justices, and the President of the United States of America floated on a regular basis, it’d be easy to imagine that the world would be a better place.

The Float Tour Blog – Issue #12
In this issue of The Float Tour Blog, we visit centers across 3 states and catch up with a few long time friends and a familiar voice to a lot of float center owners.

The Float Tour Blog – Issue #11
This issue of The Float Tour Blog focuses on our exploration into floating in the Deep South. Graham, Ashkahn, and JT tours centers in Louisiana and Georgia while also visiting the largest cryotherapy manufacturer in the USA.

The Float Tour Blog – Issue #10
Floating has definitely found a home here in the big cities: Dallas, Austin, and Houston.
Texas has several centers that started as holdouts of floating from before 2010, but new centers are popping up on a regular basis.

Fancy Acronyms for your Business Plan: TAM, SAM, and SOM
In this post, we’ll be looking at those enigmatic acronyms: TAM, SAM, and SOM, which are the backbone for the market analysis section of your written plan. We’ve helped a couple hundred float centers to develop their business plans, and we’ve found that this one area generates the most questions, and seems to generally be the most difficult to wrap your head around.